Chaumette et al. Schizophr Res. 2020


 

A polymorphism in the glutamate metabotropic receptor 7 is associated with cognitive deficits in the early phases of psychosis.  Chaumette B, Sengupta SM, Lepage M, Malla A, Iyer SN, Kebir O, Dion PA, Rouleau GA, Krebs MO, Shah JL, Joober R. Schizophr Res. 2020 Jul 2;. doi: 10.1016/j.schres.2020.06.019. [Epub ahead of print] PubMed PMID: 32624350. Download from HAL-INSERM

Schizophrenia is an illness characterized by positive symptoms, negative symptoms, and cognitive impairments. Cognitive impairments occur before the onset of psychosis and could reflect glutamatergic dysregulation. Thus, identifying associations between genetic variations in genes coding for glutamatergic receptors and cognitive impairment in schizophrenia may help in understanding the basis of these deficits and in identifying potential drug targets. In a discovery cohort of 144 first-episode of psychosis patients (FEP), we genotyped 58 candidate Single Nucleotide Polymorphisms (SNPs) located in NMDA and metabotropic glutamatergic receptors. These SNPs were selected according to the results from the Psychiatric Genomic Consortium and were tested for association with intellectual quotient (IQ) as assessed with the Wechsler Intelligence Scales. For replication, we used the ICAAR cohort including 121 ultra-high-risk patients (UHR) with the same cognitive assessment. A polymorphism located in GRM7, rs1396409, was significantly associated with performance IQ in the discovery cohort of FEP. This association was replicated in the UHR cohort. This polymorphism is also associated with total IQ and verbal IQ in the merged dataset, with a predominant effect on the arithmetic subtest. The rs1396409 polymorphism is significantly associated with cognitive impairment during the onset of psychosis. This genetic association highlights the possible impact of glutamatergic genes in cognitive deficits in the early phases of psychosis and enforces the interest for new therapeutic interventions targeting the glutamatergic pathway.

Keywords: Genetics; IQ; Premorbid; Prodromal; Psychosis; Schizophrenia.

This part of the website could either be in French or English, depending on the sources of the actualities.

SIDEBAR_ARCHIVE_TITLE

 01 December 2023
IPNP Seminar Friday December 1st, dr Julie GAVARD Glioblastoma cells walk the line with brain vessels
 28 November 2023
12h30 de la recherche - 28 novembre-Grand Amphi Blanc GHU Sainte-Anne-IPNP
 06 October 2023
IPNP Seminar Friday October 6th, Pr Angeliki LOUVI: Investigating Brain Disease: from Patients to Model Organisms and Beyond
 26 September 2023
12h30 de la recherche - 26 septembre-Grand Amphi Blanc GHU Sainte-Anne-IPNP
 06 September 2023
IPNP Seminar September 6th, Dr Daniel Medina Cano, A stem cell platform to map cell type and stage-specific cis-regulatory variation in mouse embryonic brain development
 01 September 2023
IPNP Seminar Friday September 1st, Pr Annika KELLER, Vascular calcification in the brain
 25 August 2023
Seminar Friday August 25th, Dr Mariana Tasso: Nanobiomaterials: from the beauties of the nanoworld to the quest for real biological applications
 07 July 2023
Friday, July 7th, 2023, noon: Dr Sophie STECULORUM (Host V Tolle) Max Planck Institute, Köln, Germany Sensory regulation of feeding behaviour and metabolism
 02 June 2023
IPNP Seminar June 2nd Noon Pr Christian NOLTE: Myocardial injury in acute ischemic stroke – from heart to brain and back again
 30 May 2023
12h30 de la recherche - 30 mai-Amphi Morel GHU Sainte-Anne-IPNP
 25 April 2023
Hemorrhagic Stroke: Current Research regarding Etiological Diagnosis
 07 April 2023
IPNP Seminar noon friday April 7th 2023: Pr Ype ELGERSMA-Mechanisms underlying Angelman syndrome and the promise of antisense oligonucleotide (ASO) treatment
 17 March 2023
Mitochondria and the social organelle network
 01 March 2023 20 March 2023
Semaine du Cerveau 25ème édition
 01 March 2023 14 March 2023
Conférence inaugurale de la Semaine du Cerveau: Neurosciences et Psychiatrie, un vertueux mariage
 24 February 2023 18 March 2023
NeuroFrance 2023
 02 September 2022
The reciprocal interplay between nutrient sensing and secretory pathways defines cellular homeostasis
 01 July 2022
Cortical wiring by synapsespecific control of local protein synthesis
 20 June 2022
Demars et al. Curr Biol. 2022
 10 June 2022
A "Neurotour de France" - Ep. 2, présentation of IPNP