Emplois

L’équipe de Guillaume van Niel au sein de l’Institut de Psychiatrie et Neurosciences de Paris (102 rue de la Santé, 75014 Paris) étudie le rôle des exosomes dans plusieurs neuropathies en utilisant le poisson zèbre comme organisme modèle. nous recherchons un(e) ingénieur(e) d’étude (niveau Master) pour rejoindre notre équipe sur un contrat de 30 mois.

The position will be for 3 years
Starting date: possible from September 2021; prior to December 2021
We seek to hire a highly motivated young postdoctoral fellow to work in electrophysiology in
brain slices and in vivo. A background in behavior as well as experience with transgenic mice and glial
cells would be appreciated, but not required. The post-doc candidate will integrate our team located in
the new Institute of Psychiatry and Neuroscience of Paris (IPNP) inside Sainte-Anne Hospital, a highly
stimulating environment. He/she will investigate how neuron-oligodendroglia interactions drive
neuronal circuit function and mouse behavior.
Interestingly, cortical GABAergic interneurons and some populations of oligodendroglia are
born from the same embryonic origin, migrate through similar routes and interact through synaptic
contacts once in place in the cortex. In addition, a large proportion of interneurons and oligodendroglia
are demised by programmed cell death at early postnatal stages (Orduz et al., 2019). However, the
functional relevance of interneuron-oligodendroglia interactions and their developmental cell death are
still poorly understood. The project will explore the impact of the aforementioned common features of
these cell types on cognitive processes and neurodevelopmental disorders by using a multidisciplinary
approach ex vivo and in vivo in different transgenic mice.

Neurons are the largest and most complex cells of the body and heavily rely on local protein synthesis to modify specific synapses during learning and memory formation.
Our recent work indicates that the local production of membrane proteins requires the use of a previously unrecognized trafficking pathway that bypasses the Golgi apparatus. This unconventional secretory pathway in turn enables neurons to regulate the Nglycosylation and hence the function of key surface membrane proteins.

Voir l'offre

Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM UMR-S 1266, Paris, France

Position

A post-doctoral position on the role of metabolic sensors in the neurobiology of reward in anorexia nervosa is available in the team “Genetics of Psychiatric and Addictive Disorders” (Gorwood’s team, project coordinated by Dr Virginie Tolle) at the Institute of Psychiatry and Neuroscience of Paris (https://ipnp.paris5.inserm.fr/). IPNP is dedicated to research on translational neuropsychiatry and offers onsite access to cutting-edge mouse behavioral phenotyping and neuronal imaging platforms necessary for the current project.

This project is part of a collaborative program funded by Agence Nationale pour la Recherche (ANR) and involves two teams having complementary skills in the neuroendocrine control of feeding and neurobiological mechanism of reward. This fundamental project is also part of a translational program and involves interactions with clinicians for optimal mouse to human translation of data. The position is available from October 2020 for an initial period of 18 months with possibilities of extension.