Emplois

Postdoctoral Position
Team Synaptic Plasticity and Neural Networks
Institute of Psychiatry and Neuroscience of Paris, INSERM U1266
Team heads: Vivien Chevaleyre and Rebecca Piskorowski
Duration of position: 3 yrs
Starting date: March 2021

We are currently recruiting a highly motivated postdoc to work with our team on a project examining the cellular mechanism allowing environmental factors to influence social cognition. Environmental enrichment is a promising therapeutic approach for the treatment of several psychiatric diseases. In particular, significant improvements have been observed in patients suffering from pathologies with altered social cognition such as schizophrenia and autism spectrum disorders. However, the cellular and molecular mechanisms underlying the beneficial effect of environmental enrichment are poorly understood. Area CA2 of the hippocampus, a brain structure critical for social cognition, is specifically altered during several psychiatric diseases such as schizophrenia. Importantly, we described similar alterations in a mouse model of schizophrenia, thus validating this model to study potential treatments.

See more

Nous cherchons à recruter un.e technicien.ne au sein de l’équipe dirigée par Heike Rebholz (PhD) et intitulée « Mécanismes de signalisation dans les troubles neurologiques ». Ce groupe s’intéresse à l’élucidation de l’interaction entre les kinases et les GPCR dans les troubles neurologiques, en mettant l’accent sur la maladie de Parkinson (https://ipnp.paris5.inserm.fr/recherche/equipes-et-projets/23-equipe-rebholz)

We seek to hire a highly motivated young postdoctoral fellow to investigate how neuron-oligodendroglia interactions drive cortical circuit maturation and function, impacting cognitive processes. The postdoc candidate should have expertise in electrophysiology in vivo and behavior. A background in patch-clamp recordings in brain slices as well as experience in transgenic mice and glial cells would be appreciated but not required. The post-doc candidate will integrate our team located in the new Institut of Psychiatry and Neuroscience of Paris (IPNP) inside Sainte-Anne Hospital, a highly stimulating environment.

Neurons are the largest and most complex cells of the body and heavily rely on local protein synthesis to modify specific synapses during learning and memory formation.
Our recent work indicates that the local production of membrane proteins requires the use of a previously unrecognized trafficking pathway that bypasses the Golgi apparatus. This unconventional secretory pathway in turn enables neurons to regulate the Nglycosylation and hence the function of key surface membrane proteins.

Voir l'offre

Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM UMR-S 1266, Paris, France

Position

A post-doctoral position on the role of metabolic sensors in the neurobiology of reward in anorexia nervosa is available in the team “Genetics of Psychiatric and Addictive Disorders” (Gorwood’s team, project coordinated by Dr Virginie Tolle) at the Institute of Psychiatry and Neuroscience of Paris (https://ipnp.paris5.inserm.fr/). IPNP is dedicated to research on translational neuropsychiatry and offers onsite access to cutting-edge mouse behavioral phenotyping and neuronal imaging platforms necessary for the current project.

This project is part of a collaborative program funded by Agence Nationale pour la Recherche (ANR) and involves two teams having complementary skills in the neuroendocrine control of feeding and neurobiological mechanism of reward. This fundamental project is also part of a translational program and involves interactions with clinicians for optimal mouse to human translation of data. The position is available from October 2020 for an initial period of 18 months with possibilities of extension.