IPNP Seminar Friday December 1st, dr Julie GAVARD Glioblastoma cells walk the line with brain vessels

Psychiatry and Neuroscience Seminar Series 2023

Friday, December 1st, 2023, noon

Room D Levy, 102-108 rue de la santé - 75014 Paris & VISIOCONFERENCE

Glioblastoma cells walk the line with brain vessels, Inserm U1307, CNRS UMR6075, Nantes

On the ground of our interests for molecular piracy exerted by tumor cells to survive, adapt and remodel their environment, we explore the signaling mechanisms involved in non-oncogene addiction and loss of vascular homeostasis. Glioblastoma multiforme (GBM) is a rare, yet devastating, primary brain tumor in adults. Current treatments remain generally ineffective and GBM almost invariably recurs, resulting in median survival of 15 months. Within GBM, exists a population of self-sustaining transformed cells with stem-like properties (GSCs), which are thought to be responsible for tumor initiation, growth, and invasion, as well as recurrence. In the tumor microenvironment, GSCs might be found in the vicinity of brain endothelial cells, which provide a protective habitat. Herein, we established an ex vivo model to explore GSC invasive behavior. We found that patient-derived cells massively invade the collagen matrix. In addition, we described that the glycoprotein Neuropilin-1 (NRP1) contributes to GSC spreading and invasion. Indeed, both RNA interference-mediated silencing and CRISPR-mediated gene editing deletion of NRP1 strongly impaired the 3D invasive properties of patient-derived GSCs and their close localization to the brain blood vessels. Of note, other typical features of GSCs, such as expansion and self-renewal were maintained. From a mechanistic standpoint, this biological effect might rely on the expression of the β3 subunit integrin cell-extracellular matrix adhesive receptor. Our data, therefore, propose a reliable approach to explore invasive properties of patient glioma cells ex vivo and identify NRP1 as a mediator in this malignant process.


Extracellular Vesicle, Intracellular Signaling, Trafficking, Tumor Cells


Stay tuned

This part of the website could either be in French or English, depending on the sources of the actualities.


 01 décembre 2023
IPNP Seminar Friday December 1st, dr Julie GAVARD Glioblastoma cells walk the line with brain vessels
 28 novembre 2023
12h30 de la recherche - 28 novembre-Grand Amphi Blanc GHU Sainte-Anne-IPNP
 06 octobre 2023
IPNP Seminar Friday October 6th, Pr Angeliki LOUVI: Investigating Brain Disease: from Patients to Model Organisms and Beyond
 26 septembre 2023
12h30 de la recherche - 26 septembre-Grand Amphi Blanc GHU Sainte-Anne-IPNP
 06 septembre 2023
IPNP Seminar September 6th, Dr Daniel Medina Cano, A stem cell platform to map cell type and stage-specific cis-regulatory variation in mouse embryonic brain development
 01 septembre 2023
IPNP Seminar Friday September 1st, Pr Annika KELLER, Vascular calcification in the brain
 25 août 2023
Seminar Friday August 25th, Dr Mariana Tasso: Nanobiomaterials: from the beauties of the nanoworld to the quest for real biological applications
 07 juillet 2023
Friday, July 7th, 2023, noon: Dr Sophie STECULORUM (Host V Tolle) Max Planck Institute, Köln, Germany Sensory regulation of feeding behaviour and metabolism
 02 juin 2023
IPNP Seminar June 2nd Noon Pr Christian NOLTE: Myocardial injury in acute ischemic stroke – from heart to brain and back again
 30 mai 2023
12h30 de la recherche - 30 mai-Amphi Morel GHU Sainte-Anne-IPNP
 25 avril 2023
Hemorrhagic Stroke: Current Research regarding Etiological Diagnosis
 07 avril 2023
IPNP Seminar noon friday April 7th 2023: Pr Ype ELGERSMA-Mechanisms underlying Angelman syndrome and the promise of antisense oligonucleotide (ASO) treatment
 17 mars 2023
Mitochondria and the social organelle network
 01 mars 2023 20 mars 2023
Semaine du Cerveau 25ème édition
 01 mars 2023 14 mars 2023
Conférence inaugurale de la Semaine du Cerveau: Neurosciences et Psychiatrie, un vertueux mariage
 24 février 2023 18 mars 2023
NeuroFrance 2023
 02 septembre 2022
The reciprocal interplay between nutrient sensing and secretory pathways defines cellular homeostasis
 01 juillet 2022
Cortical wiring by synapsespecific control of local protein synthesis
 20 juin 2022
Demars et al. Curr Biol. 2022
 10 juin 2022
A "Neurotour de France" - Ep. 2, présentation of IPNP