le mercredi 31 mars 2021
Les chercheurs de l’IPNP ont besoin de vos dons pour développer et mettre en place les projets de recherche. Pour connaître nos équipes et obtenir le bulletin de soutien, merci de cliquer sur Lire la suite...
Lire la suite
le jeudi 18 février 2021
It is with great sadness that we share news of the passing of Deborah Levy. Since 2015, Debbie had been a member of IPNP international Scientific Advisory Board. She participated in every single evaluation during the last five years, including 3 open calls and the evaluation of our 2019-2024 plan. During this time, Debbie befriended many IPNP scientists. We benefitted not only from her intelligence and scientific insight, but also enjoyed her humor and warmth. The entire iSAB and IPNP community mourn...
Lire la suite
le mardi 09 mars 2021
Altered Neuronal Support and Inflammatory Response in Bipolar Disorder Patient-Derived Astrocytes. Vadodaria KC, Mendes APD, Mei A, Racha V, Erikson G, Shokhirev MN, Oefner R, Heard KJ, McCarthy MJ, Eyler L, Kelsoe JR, Santos R, Marchetto MC, Gage FH. Stem Cell Reports. 2021 Feb 23;. doi: 10.1016/j.stemcr.2021.02.004. [Epub ahead of print] PubMed PMID: 33667413. Download from HAL-INSERM This article has been chosen for a Press Release by Cell Press in the AAAS platform EurekAlert. The article...
Lire la suite
du jeudi 18 mars 2021 au vendredi 19 mars 2021
Les 18 et 19 mars, 2021, Institut Imagine, Inserm U1163 Le jeudi 18 mars comporte des présentations scientifiques en particulier sur la question de la génétique de la schizophrénie et de l'autisme. Le vendredi 19 mars est davantage axé sur la place de la génétique dans la pratique clinique. Comité d’organisation : Pr Pauline Chaste Dr Boris Chaumette Pr Raphaël Gaillard Pr Stanislas Lyonnet Toutes les conférences seront en ligne et gratuites: Programme ci-joint ZOOM...
Lire la suite
le jeudi 25 février 2021
Can Enhancing Neuronal Activity Improve Myelin Repair in Multiple Sclerosis? Maas DA, Angulo MC. Front. Cell. Neurosci., 23 February 2021. doi: 10.3389/fncel.2021.645240. Download from HAL-INSERM Enhanced neuronal activity in the healthy brain can induce de novo myelination and behavioral changes. As neuronal activity can be achieved using non-invasive measures, it may be of interest to utilize the innate ability of neuronal activity to instruct myelination as a novel strategy for myelin...
Lire la suite
le mercredi 17 février 2021
One year after the COVID-19: what have we learnt, what shall we do next?. Gorwood P, Fiorillo A. Eur Psychiatry. 2021 Feb 15; 1-5. doi: 10.1192/j.eurpsy.2021.9. [Epub ahead of print] PubMed PMID: 33583453. Download from HAL-INSERM We are still within the acute phase of the COVID-19 pandemic, so getting lessons of how we coped with it during its first year of life is of interest. The European Psychiatric Association (EPA) has been trying to help patients, caregivers and policy makers to concentrate...
Lire la suite
le mercredi 17 février 2021
ER-PM Contact Sites – SNARING Actors in Emerging Functions. Hewlett B, Pratap Singh N, Vannier C, Galli T. Front. Cell Dev. Biol., 11 February 2021. https://doi.org/10.3389/fcell.2021.635518 Download from HAL-INSERM Review Article The compartmentalisation achieved by confining cytoplasm into membrane-enclosed organelles in eukaryotic cells is essential for maintaining vital functions including ATP production, synthetic and degradative pathways. While intracellular organelles are highly specialised...
Lire la suite
le vendredi 12 février 2021
Introducing secretory reticulophagy/ER-phagy (SERP), a VAMP7-dependent pathway involved in neurite growth. Vats S, Galli T. Autophagy. 2021 Feb 8;:1-3. doi: 10.1080/15548627.2021.1883886. [Epub ahead of print] PubMed PMID: 33554711. Download from HAL-INSERM Together with the proteasome, macroautophagy is a main pathway for the degradation of intracellular elements. Endoplasmic reticulum (ER)-autophagy i.e. reticulophagy/ER-phagy leads to the...
Lire la suite
le vendredi 05 février 2021
Press Release: Renata Santos, Researcher at the Institut de Psychiatrie et Neurosciences de Paris (IPNP) FORBES Editors' Pick|Jan 26, 2021,12:22pm EST|1 920 views The Standard Treatment For Bipolar Disorder Doesn’t Work For Everyone, And Now Scientists Might Know Why Jackie Rocheleau, Contributor Lithium is often the first treatment option for bipolar disorder. But it’s only effective for about a third of people with the disorder. Scientists may have a clue as to why and discovered...
Lire la suite
le lundi 01 février 2021
Impact of the timing and adherence to face mask use on the course of the COVID-19 epidemic in France. Hoertel N, Blachier M, Sánchez-Rico M, Limosin F, Leleu H. J Travel Med. 2021 Jan 28;. doi: 10.1093/jtm/taab016. [Epub ahead of print] PubMed PMID: 33506243. Download from HAL-INSERM In this report, we sought to examine whether an early implementation of face mask use with an achievable adherence of 80% in the population would have reduced cumulative COVID-19 incidence, mortality, and...
Lire la suite
le jeudi 28 janvier 2021
Nascent fusion pore opening monitored at single-SNAREpin resolution. Heo P, Coleman J, Fleury JB, Rothman JE, Pincet F. Proc Natl Acad Sci U S A. 2021 Feb 2;118(5). doi: 10.1073/pnas.2024922118. PubMed PMID: 33495324. Download from HAL-INSERM Significance Using our recently designed microfluidic setup, we investigated the early stage of SNAREpin-induced fusion. We discovered the existence of subsecond transient fusion pores with a well-defined subnanometer size that occur when one or...
Lire la suite
le mardi 26 janvier 2021
Characterization of early ultrastructural changes in the cerebral white matter of CADASIL small vessel disease using high pressure freezing/freeze-substitution. Rajani RM, Dupré N, Domenga-Denier V, Van Niel G, Heiligenstein X, Joutel A. Neuropathol Appl Neurobiol. 2021 Jan 23;. doi: 10.1111/nan.12697. [Epub ahead of print] PubMed PMID: 33483954. Download from HAL-INSERM Aims: The objective of this study was to elucidate the early white matter changes in CADASIL small vessel disease. Methods:...
Lire la suite
le mercredi 13 janvier 2021
Prediction of Early Neurological Deterioration in Individuals With Minor Stroke and Large Vessel Occlusion Intended for Intravenous Thrombolysis Alone. Seners P, Ben Hassen W, Lapergue B, Arquizan C, Heldner MR, Henon H, Perrin C, Strambo D, Cottier JP, Sablot D, Girard Buttaz I, Tamazyan R, Preterre C, Agius P, Laksiri N, Mechtouff L, Béjot Y, Duong DL, Mounier-Vehier F, Mione G, Rosso C, Lucas L, Papassin J, Aignatoaie A, Triquenot A, Carrera E, Niclot P, Obadia A, Lyoubi A, Garnier P, Crainic...
Lire la suite