le vendredi 02 octobre 2020
Les chercheurs de l’IPNP ont besoin de vos dons pour développer et mettre en place les projets de recherche. Pour connaître nos équipes et obtenir le bulletin de soutien, merci de cliquer sur Lire la suite...
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le lundi 26 octobre 2020
Le Prix Scientifique Jean-Paul Binet est issu d’une donation de Jean-Paul Binet. Il est destiné à récompenser des travaux de recherches cliniques ou expérimentales sur les pathologies cardiovasculaires ou sur les xénogreffes. Lauréat : Jean-Louis Mas Professeur de Neurologie à l’Université de Paris Chef du service de Neurologie de l’hôpital Sainte-Anne, Paris Responsable de l’équipe « Accidents vasculaires cérébraux : déterminants du pronostic, recherche translationnelle,...
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le lundi 26 octobre 2020
How Do Electric Fields Coordinate Neuronal Migration and Maturation in the Developing Cortex? Medvedeva, V, Pierani, A. Front. Cell Dev. Biol. 2020 Sep 8: 1006.doi:10.3389/fcell.2020.580657 Download from HAL-INSERM : https://www.hal.inserm.fr/inserm-02973314 During development the vast majority of cells that will later compose the mature cerebral cortex undergo extensive migration to reach their final position. In addition to intrinsically distinct migratory behaviors, cells encounter and...
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le mardi 13 octobre 2020
Myelination of parvalbumin interneurons shapes the function of cortical sensory inhibitory circuits. Benamer N, Vidal M, Balia M, Angulo MC. Nat Commun 11, 5151 (2020). https://doi.org/10.1038/s41467-020-18984-7 Abstract Myelination of projection neurons by oligodendrocytes is key to optimize action potential conduction over long distances. However, a large fraction of myelin enwraps the axons of parvalbumin-positive fast-spiking interneurons (FSI), exclusively involved in local cortical circuits....
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le lundi 05 octobre 2020
A hypothalamic novelty signal modulates hippocampal memory. Chen S, He L, Huang AJY, Boehringer R, Robert V, Wintzer ME, Polygalov D, Weitemier AZ, Tao Y, Gu M, Middleton SJ, Namiki K, Hama H, Therreau L, Chevaleyre V, Hioki H, Miyawaki A, Piskorowski RA, McHugh TJ. Nature. 2020 Sep 30;. doi: 10.1038/s41586-020-2771-1. [Epub ahead of print] PubMed PMID: 32999460. Abstract The ability to recognize information that is incongruous with previous experience is critical for survival. Novelty signals...
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le mercredi 23 septembre 2020
Role of the Sec22b-E-Syt complex in neurite growth and ramification. Gallo A, Danglot L, Giordano F, Hewlett B, Binz T, Vannier C, Galli T. J Cell Sci. 2020 Sep 15;133(18):jcs247148. doi: 10.1242/jcs.247148. PMID: 32843578. Download from HAL-INSERM Abstract Axons and dendrites are long and often ramified neurites that need particularly intense plasma membrane (PM) expansion during the development of the nervous system. Neurite growth depends on non-fusogenic Sec22b-Stx1 SNARE complexes at...
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le lundi 07 septembre 2020
Functional imaging evidence for task-induced deactivation and disconnection of a major default mode network hub in the mouse brain. Ferrier J, Tiran E, Deffieux T, Tanter M, Lenkei Z. Proc Natl Acad Sci U S A. 2020 Jun 30;117(26):15270-15280. doi: 10.1073/pnas.1920475117. Epub 2020 Jun 15. PubMed PMID: 32541017; PubMed Central PMCID: PMC7334502. Abstract The default mode network (DMN) has been defined in functional brain imaging studies as a set of highly connected brain areas, which are...
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le mardi 01 septembre 2020
Inositol monophosphatase 1 (IMPA1) mutation in intellectual disability patients impairs neurogenesis but not gliogenesis. Figueiredo T, Mendes APD, Moreira DP, Goulart E, Oliveira D, Kobayashi GS, Stern S, Kok F, Marchetto MC, Santos R*, Gage FH*, Zatz M*. Mol Psychiatry. 2020 Aug 24;. doi: 10.1038/s41380-020-00862-9. [Epub ahead of print] PubMed PMID: 32839513. *These authors contributed equally https://www.nature.com/articles/s41380-020-00862-9.epdf?sharing_token=Q8IpW6t0GDhdqUxyF-khStRgN0jAjWel9jnR3ZoTv0M89EaNKtLbCT8dDnFnig3ee2iYQ6nYWPa6n88smnSw12yONRyIDX1WfFVmbZrSjQ0z3LAsO_tAqFDvr0-cScw01bcHBLJX450ZHYs2GxIUbMA0MExE_18kYsp6dc_FTO4%3D Abstract A...
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le mardi 29 septembre 2020
Cytotoxic lesion of the corpus callosum as presenting neuroradiological manifestation of COVID-2019 infection. Forestier G, de Beaurepaire I, Bornet G, Boulouis G. J Neurol. 2020 Aug 18;. doi: 10.1007/s00415-020-10166-1. [Epub ahead of print] PubMed PMID: 32809155; PubMed Central PMCID: PMC7433278. Since December 2019, severe acute respiratory syndrome (SARS) cases related to the coronavirus disease-2019 (COVID-19) emerged from Wuhan, Hubei Province, China [1–3] and spread all around...
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le mardi 01 septembre 2020
Extracellular vesicles: eat glutamine and spit acidic bubbles. van Niel G, Théry C. EMBO J. 2020 Aug 17;39(16):e105119. doi: 10.15252/embj.2020105119. Epub 2020 Jul 28. PubMed PMID: 32809264; PubMed Central PMCID: PMC7429734. Abstract Extracellular vesicles mediate transfer of diverse molecular content to target cells in order to induce phenotypic changes, which has put them under the spotlight as likely major players in cell-to-cell communication. However, extracellular vesicle heterogeneity...
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le jeudi 20 août 2020
Contenu: Addictions in the COVID-19 era: Current evidence, future perspectives a comprehensive review. Mallet J, Dubertret C, Le Strat Y. Prog Neuropsychopharmacol Biol Psychiatry. 2020 Aug 12:110070. doi: 10.1016/j.pnpbp.2020.110070. Epub ahead of print. PMID: 32800868; PMCID: PMC7420609. Background: In the context of the COVID-19 worldwide pandemic, an up-to-date review of current challenges in addictions is necessary. While large scale disasters may have an impact on substance use and addictions,...
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le jeudi 20 août 2020
Whole-Cell Photobleaching Reveals Time-Dependent Compartmentalization of Soluble Proteins by the Axon Initial Segment. Nicholson L, Gervasi N, Falières T, Leroy A, Miremont D, Zala D, Hanus C. Front. Cell. Neurosci., 10 July 2020 | https://doi.org/10.3389/fncel.2020.00180. By limiting protein exchange between the soma and the axon, the axon initial segment (AIS) enables the segregation of specific proteins and hence the differentiation of the somatodendritic compartment and the axonal compartment....
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