IPNP Seminar Tuesday January 23rd, Pr Frederic MEUNIER Greasing the wheel of memory via a novel phospholipase A1 pathway, University of Queensland, Australia


Psychiatry and Neuroscience Seminar Series 2024

Tuesday, January 23rd, 2024, noon

Room D Levy, 102-108 rue de la santé - 75014 Paris 
Pr Frédéric A MEUNIER

Greasing the wheel of memory via a novel phospholipase A1 pathway,Single Molecule Neuroscience Laboratory, Queensland Brain Institute, University of Queensland, Australia

The goal of our research is to determine how brain cells communicate and survive in health and disease. We are focused on the molecular events that govern vesicular trafficking within presynaptic nerve terminals and neurosecretory cells. Our discoveries have led to a deep understanding of how secretory vesicles interact with the cortical actin network prior to fusing with the plasma membrane to release the neurotransmitter. One of the last frontiers in neurobiology is to understand how our brain can learn and store memories - some of them enduring for a lifetime. Saturated FFAs, particularly myristic and palmitic acids, strongly increase during neuronal stimulation and memory acquisition, suggesting the involvement of phospholipase A1 (PLA1) activity in synaptic plasticity. I will present some of our work demonstrating that the DDHD2 isoform of PLA1 generates these saturated FFAs across the brain, thereby controlling memory performance in reward-based learning and spatial memory models prior to the development of neuromuscular deficits. We found that DDHD2 interacts with the key synaptic protein STXBP1/Munc18-1. Both DDHD2 knockout and haplo-insufficient STXBP1+/- mice display intellectual disability and motor dysfunction. We also show that STXBP1 controls the targeting of DDHD2 to the plasma membrane and the generation of saturated FFAs in the brain. Our findings suggest key roles for DDHD2 and STXBP1 in the lipid metabolism underlying synaptic plasticity, learning and memory.

Keywords:

Neurobiology, Synapse, Single Molecule Imaging

CY

Stay tuned


This part of the website could either be in French or English, depending on the sources of the actualities.

Autres Séminaires

 01 janvier 2023 31 décembre 2023
Psychiatry and Neuroscience Seminar Series 2023
 12 avril 2023 20 avril 2023
IPNP Young Researcher's Day April 20th, 2023
 01 janvier 2024 31 décembre 2024
Psychiatry and Neuroscience Seminar Series 2024
 11 janvier 2024 23 janvier 2024
IPNP Seminar Tuesday January 23rd, Pr Frederic MEUNIER Greasing the wheel of memory via a novel phospholipase A1 pathway, University of Queensland, Australia
 30 janvier 2024
12h30 de la recherche - 30 janvier-Grand Amphi Blanc GHU Sainte-Anne-IPNP
 09 février 2024
IPNP Seminar Friday February 9th, Dr Rachida AMMARI, Hormone-mediated neural remodeling orchestrates parenting onset during pregnancy, The Francis Crick Institute, London, UK
 01 mars 2024
IPNP Seminar Friday March 1st, Jean-Michel PEYRIN, Reconstructing rodent and human Neuronal Networks to model Neurodegenerative syndromes, IBPS, France
 19 mars 2024
IPNP Seminar Tuesday, March 19th 2024, noon, Nicolo ACCANTO: Beyond 2P microscopy: optogenetic probing of large and deep neuronal circuits in freely moving mice
 26 mars 2024
12h30 de la recherche - 26 mars-Grand Amphi Blanc GHU Sainte-Anne-IPNP
 05 avril 2024
IPNP Seminar Friday April 5th noon, Nicolas RENIER, The development and plasticity of the post-natal cerebral vasculature
 26 avril 2024
IPNP Friday April 26th 11am, Raunak Basu, Mapping the world around us: A topology-preserved schema of space that supports goal-directed navigation
 03 mai 2024
IPNP Seminar Friday May 3rd noon, Laurent NGUYEN, Regulation of cerebral cortex morphogenesis by migrating cells
 29 août 2024 10 septembre 2024
IPNP SEMINAR FRIDAY SEPTEMBER 6TH NOON, Dr Urs Lucas BÖHM, The networks that make us move: voltage imaging in the zebrafish spinal cord
 24 septembre 2024
12h30 de la recherche -24 septembre Salle Levy 4ème IPNP
 04 octobre 2024
IPNP SEMINAR FRIDAY OCTOBER 4TH NOON, Dr Marta BORTOLETTO, Emerging trends in the application of TMS-EEG coregistration in psychiatry
 08 novembre 2024
IPNP SEMINAR FRIDAY NOVEMBER 8TH NOON, Pr Martin Horák, Investigation of early transport of NMDA receptors by pathogenic variants in extracellular domains of GluN subunits and their pharmacological modulation by novel open-channel blockers