This talk will examine hippocampal parvalbumin (PV) inhibitory neurons as key regulators of network stability and memory function in Alzheimer’s disease models. We address how alterations in PV cell activity and in perineuronal nets, specialized extracellular matrix structures that stabilize synaptic connectivity and regulate plasticity, reshape circuit synchronization and influence the behavioral expression of pathology.
Using convergent approaches that enhance PV neuronal maturation or activity, including trophic modulation, environmental enrichment and chemogenetic activation, we test whether re-engaging PV-driven circuit function can promote functional recovery and inform mechanisms of cognitive reserve, reframing Alzheimer’s disease in terms of circuit resilience rather than solely neurodegeneration.
This part of the website could either be in French or English, depending on the sources of the actualities.