Demars et al. Curr Biol. 2022


Post-trauma behavioral phenotype predicts the degree of vulnerability to fear relapse after extinction in male rats.  Demars F, Todorova R, Makdah G, Forestier A, Krebs MO, Godsil BP, Jay TM, Wiener SI, Pompili MN. Curr Biol. 2022 Jun 9;. doi: 10.1016/j.cub.2022.05.050. [Epub ahead of print] PubMed PMID: 35705096. Download from HAL-INSERM


Current treatments for trauma-related disorders remain ineffective for many patients.1,2 Fear extinction deficiency is a prominent feature of these diseases,3 and many behavioral treatments rely on extinction training.4,5 However, in many patients, therapy is followed by a relapse of symptoms, and the underpinnings of such interindividual variations in vulnerability to relapse remain unknown.6-8 Here, we modeled interindividual differences in post-therapy fear relapse with an ethologically relevant trauma recovery paradigm. After fear conditioning, male rats underwent fear extinction while foraging in a large enriched arena, permitting the expression of a wide spectrum of behaviors. An automated multidimensional behavioral assessment revealed that post-conditioning fear response profiles clustered into two groups: some animals expressed fear by freezing more, whereas others darted more, as if fleeing from danger. Remarkably, the tendency of an animal to dart or to freeze after CS presentation during the first extinction session was, respectively, associated with stronger or weaker fear renewal. Moreover, genome-wide transcriptional profiling revealed that these groups differentially regulated specific sets of genes, some of which were previously implicated in anxiety and trauma-related disorders. Our results suggest that post-trauma behavioral phenotypes and the associated gene expression landscapes can serve as markers of fear relapse susceptibility and thus may be instrumental for future development of more effective treatments for psychiatric patients.


Keywords: animal model; ethological relevance; fear relapse; interindividual differences; transcriptional profiling; vulnerability.

This part of the website could either be in French or English, depending on the sources of the actualities.


 25 April 2023
Hemorrhagic Stroke: Current Research regarding Etiological Diagnosis
 01 March 2023 20 March 2023
Semaine du Cerveau 25ème édition
 01 March 2023 14 March 2023
Conférence inaugurale de la Semaine du Cerveau: Neurosciences et Psychiatrie, un vertueux mariage
 24 February 2023 18 March 2023
NeuroFrance 2023
 02 September 2022
The reciprocal interplay between nutrient sensing and secretory pathways defines cellular homeostasis
 01 July 2022
Cortical wiring by synapsespecific control of local protein synthesis
 20 June 2022
Demars et al. Curr Biol. 2022
 10 June 2022
A "Neurotour de France" - Ep. 2, présentation of IPNP
 03 June 2022
Programming neural cells for disease modelling and therapy development
 31 May 2022
Call for group leaders
 06 May 2022
Phenomenology and pathophysiology of antipsychotic-induced compulsive behaviour
 01 April 2022
Medial Septum cholinergic inputs to CA2: a new role in social novelty discrimination
 21 March 2022
Olié et al. Cereb Cortex. 2022
 04 March 2022
Molecular Dissection of Selective Neuronal Vulnerability in Alzheimer's Disease
 23 February 2022
Sánchez-Rico et al. J Travel Med. 2022
 04 February 2022
Quantitative analysis and modelling of dendrite growth
 20 January 2022
Hoertel et al. Biol Psychiatry Glob Open Sci. 2022
 07 January 2022
Neurobiology of social and non social decision-making processes in mouse models
 21 December 2021 31 December 2021
Psychiatry and Neuroscience Seminar Series 2021
 03 December 2021
Deconstructing the role of dopamine signaling in defensive behaviors