Team Oppenheim

Imaging biomarkers of brain disorders (IMA-brain)

Team leader :  Catherine Oppenheim

Team member :  Wagih BEN HASSEN  |   Joseph Ben Zakoun  |   Grégoire Boulouis  |   Sylvain Charron  |   Clément Debacker  |   Myriam Edjali-Goujon  |   Anna Fayolle  |   Anton François  |   Basile Kerleroux  |   Laurence Legrand  |   Jean-François Meder  |   Charles Mellerio  |   Iris Menu  |   Olivier Nagarra  |   Sixtine Omont  |   Johan Pallud  |   Marion Plaze  |   Gabriela Rezende  |   Alexandre Roux  |   Denis Trystram  |   Pascale Varlet  |   Luis Villanueva  |   Marc Zanello

Key contributors :  Elsa Angelini  |   Isabelle Bloch  |   Arnaud Cachia  |   Philippe Ciuciu  |   Joan-Alexis Glaunes  |   Pietro Gori  |   Nicolas Lomenie  |   Bertrand Thirion


As part of the center of Psychiatry and Neurosciences research center (INSERM U894, Dir T Galli), the “Imaging Biomarkers of Brain Development and Disorders (Ima-Brain)” research team (Dir. C Oppenheim) focuses on selective and complementary applications (Cerebro-Vascular, Neuro-Oncology, and Neurodevelopment) in order to tackle common basic challenges: progression over time, multiscale analysis and structure-function relationships. The team is organized around three main application axes, each coordinated by subgroup leaders with internationally recognized expertise. Together, the three axes cover a spectrum of normal and pathological conditions, each with different time scales: acute onset (stroke), rapid or slow progression (brain tumors), or lifelong evolution (neurodevelopment). A synergy between the three axes fosters, in an interdisciplinary context, the sharing of (1) methods for developing imaging biomarkers and (2) theoretical approaches across application domains.






Roux A, Roca P, Edjlali M, Sato K, Zanello M, Dezamis E, Gori P, Lion S, Fleury A, Dhermain F, Meder JF, Chrétien F, Lechapt E, Varlet P, Oppenheim C, Pallud J.MRI Atlas of IDH Wild-Type Supratentorial Glioblastoma: Probabilistic Maps of Phenotype, Management, and Outcomes. Radiology. 2019 Oct 8:190491. doi: 10.1148/radiol.2019190491.


Boulouis G, Bricout N, Benhassen W, Ferrigno M, Turc G, Bretzner M, Benzakoun J, Seners P, Personnic T, Legrand L, Trystram D, Rodriguez-Regent C, Charidimou A, Rost NS, Bracard S, Cordonnier C, Oppenheim C, Naggara O, Henon H. White matter hyperintensity burden in ischemic stroke patients treated with thrombectomy.Neurology. 2019 Sep 13. pii: 10.1212/WNL.0000000000008317.


Cachia A, Amad A, Brunelin J, Krebs MO, Plaze M, Thomas P, Jardri R. Deviations in cortex sulcation associated with visual hallucinations in schizophrenia. Molecular Psychiatry. 2015;20:1101-7. IF 15.147


Kuchcinski G, Mellerio C, Pallud J, Dezamis E, Turc G, Rigaux-Viodé O, Malherbe C, Roca P, Leclerc X, Varlet P, Chrétien F, Devaux B, Meder JF, Oppenheim C. Three-tesla functional MR language mapping: comparison with direct cortical stimulation in gliomas. Neurology. 2015;84:560-8. IF 8.29


Mellerio C, Roca P, Chassoux F, Danière F, Cachia A, Lion S, Naggara O, Devaux B, Meder JF, Oppenheim C. The Power Button Sign: A Newly Described Central Sulcal Pattern on Surface Rendering MR Images of Type 2 Focal Cortical Dysplasia. Radiology. 2015;274:500-7. IF 6.87



Comming soon