Team Pardi

Neuronal Circuits for Memory and Perception

As soon as life begins, we start perceiving external stimuli and forming our impressions of the world. Accurate perception is essential for our survival and is affected in major neuropsychiatric disorders.

However, the biological bases of adaptive perception are little understood. How do we make sense of the vast repertoire of stimuli that are captured by our sensory organs at every moment?

Our brain needs to put together the sensory information with its context, determined by our previous experiences stored in the form of memories.

We aim to identify key neuronal circuits for sensory perception, and find the mechanisms by which learning and disorders modify them, pointing to novel therapeutic targets.


Neuronal circuits for adaptive sensory perception


5 Main Publications:

Schroeder A, Pardi MB, Keijser J, Dalmay T, Groisman AI, Schuman EM, Sprekeler H, Letzkus JJ. Inhibitory top-down projections from zona incerta mediate neocortical memory. Neuron. 2023 Mar 1;111(5):727-738.e8. doi: 10.1016/j.neuron.2022.12.010. Epub 2023 Jan 6.


Pardi MB, Schroeder A & Letzkus JJ, (2022) Probing top-down information in neocortical layer 1. Trends Neurosci. doi:


Pardi MB, Vogenstahl J, Dalmay T, Spanò T, Pu DL, Naumann LB, Kretschmer F, Sprekeler H, Letzkus JJ. A thalamocortical top-down circuit for associative memory. Science. 2020 Nov 13;370(6518):844-848. doi: 10.1126/science.abc2399.


Pardi MB, Abs E, Letzkus JJ. Disinhibition Goes Spatial. Neuron. 2019 Mar 20;101(6):994-996. doi: 10.1016/j.neuron.2019.03.006.


Abs E, Poorthuis RB, Apelblat D, Muhammad K, Pardi MB, Enke L, Kushinsky D, Pu DL, Eizinger MF, Conzelmann KK, Spiegel I, Letzkus JJ. Learning-Related Plasticity in Dendrite-Targeting Layer 1 Interneurons. Neuron. 2018 Nov 7;100(3):684-699.e6. doi: 10.1016/j.neuron.2018.09.001.