Team Huberfeld

Our research has a translational focus on brain dysfunctions in neurological diseases, notably epilepsy and cerebral tumors with an emphasis on the human brain. Most experiments are conducted either in vivo or on postoperative tissues.

Our lab studies electrophysiological signals generated by neuronal activity and synaptic interactions between neurons, together with the cellular and synaptic signaling mechanisms at play in brain disorders. This approach permits progress in understanding :

1. The role played by chronic reorganization in the neuronal network signaling during epilepsy, focusing on interneurons / pyramidal cells and chloride / potassium interactions initiating seizures.
2. Neuronal interactions with lesions such as tumors with a focus on glutamatergic signaling related to glioma cells and neuronal activity
3. Neuroplasticity induced by focused ultrasound
4. Developing innovative electrodes for high resolution recording and brain disease biomarkers identification.

5 Main Publications:

Milior G, Morin-Brureau M, Pallud J, Miles R, Huberfeld G. Animal models and human tissue compared to better understand and treat the epilepsies. Epilepsia. 2023 May;64(5):1175-1189. doi: 10.1111/epi.17552. Epub 2023 Mar 6. Review.

Pallud J, Huberfeld G, Dezamis E, Peeters S, Moiraghi A, Gavaret M, Guinard E, Dhermain F, Varlet P, Oppenheim C, Chrétien F, Roux A, Zanello M. Effect of Levetiracetam Use Duration on Overall Survival of Isocitrate Dehydrogenase Wild- Type Glioblastoma in Adults: An Observational Study. Neurology. 2022 Jan 11;98(2):e125-e140. doi: 10.1212/WNL.0000000000013005. Epub 2021 Oct 21.

Huberfeld G, Ben Salah A, Pichit P, Psimaras D, Demeret S, Naccache L. Oculomotor artefacts mimic extreme deltabrush EEG features of autoimmune anti NMDA receptor encephalitis. Clin Neurophysiol. 2021 Jun;132(6):1200-1202. doi: 10.1016/j.clinph.2021.02.393. Epub 2021 Mar 31.

Blauwblomme T, Dossi E, Pellegrino C, Goubert E, Iglesias BG, Sainte-Rose C, Rouach N, Nabbout R, Huberfeld G. Gamma-aminobutyric acidergic transmission underlies interictal epileptogenicity in pediatric focal cortical dysplasia. Ann Neurol. 2019 Feb;85(2):204-217. doi: 10.1002/ana.25403. Epub 2019 Jan 17.

Dossi E, Blauwblomme T, Moulard J, Chever O, Vasile F, Guinard E, Le Bert M, Couillin I, Pallud J, Capelle L, Huberfeld G, Rouach N. Pannexin-1 channels contribute to seizure generation in human epileptic brain tissue and in a mouse model of epilepsy. Sci Transl Med. 2018 May 30;10(443). doi: 10.1126/scitranslmed.aar3796.